Irene Grandi was born in Florence. She debuted in the San Remo Music Festival in the category New Proposed with "Fuori", in 1994, which was later won by Andrea Bocelli, who was also debuting the same year. She participated as a contestant in the 60th edition of the San Remo Music Festival in 2010 with her song La cometa di Halley (Halley's Comet).